Cities and counties have banned plastic bags

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HSC70 and HSP70 proteins comprise a peptide binding domain that interacts with denatured polypeptides and a regulatory ATPase domain. BAG 1 interacts with the ATPase domain, leaving the peptide binding domain available for further interactions with protein substrates. BAG 1 regulates the chaperone function of HSC70 and HSP70 (Hohfeld, 1998) and mutation of specific amino acid residues important for binding to chaperone proteins abrogates at least some BAG 1 functions (Briknarova et al, 2001)..

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